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Replicative senescence 88

We have seen, in the first part, that aging was caused by the organism’s insufficient defenses when faced with repeated and increasingly frequent attacks on our DNA, which will, by duplicating itself when it is inadequately repaired, produce deficient copies, which will then generate deficient proteins. A process of gradual senescence which is harmful to our health and to our longevity.

Unfortunately, even if this very significant problem had a solution, we would still find ourselves confronted with a second, just as significant one, called ‘replicative senescence’. Our cells, at some point, refuse to continue replicating, commit suicide or become inactive. Why? This is the fascinating story of telomeres and of a very special enzyme which has gotten a lot of attention recently: telomerase.


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